{"id":19848,"date":"2025-06-15T17:20:35","date_gmt":"2025-06-15T15:20:35","guid":{"rendered":"https:\/\/thesmartcityjournal.cibeles.net\/sin-categoria\/startups-biosensor-makes-drug-development-and-manufacturing-cheaper\/"},"modified":"2025-06-15T17:31:08","modified_gmt":"2025-06-15T15:31:08","slug":"startups-biosensor-makes-drug-development-and-manufacturing-cheaper","status":"publish","type":"post","link":"https:\/\/www.thesmartcityjournal.com\/en\/business\/startups-biosensor-makes-drug-development-and-manufacturing-cheaper","title":{"rendered":"Startup\u2019s biosensor makes drug development and manufacturing cheaper"},"content":{"rendered":"

Protein sensor developed by alumna-founded Advanced Silicon Group can be used for research and quality control in biomanufacturing<\/span><\/i><\/p>\n

In the biotech and pharmaceutical industries, ELISA tests provide critical quality control during drug development and manufacturing. The tests can precisely quantify protein levels, but they also require hours of work by trained technicians and specialized equipment. That makes them prohibitively expensive, driving up the costs of drugs and putting research testing out of reach for many.<\/span><\/p>\n

Now the Advanced Silicon Group (ASG), founded by Marcie Black \u201994, MEng \u201995, PhD \u201903 and Bill Rever, is commercializing a new technology that could dramatically lower the time and costs associated with protein sensing. ASG\u2019s proprietary sensor combines silicon nanowires with antibodies that can bind to different proteins to create a highly sensitive measurement of their concentration in a given solution.<\/span><\/p>\n

The tests can measure the concentration of many different proteins and other molecules at once, with results typically available in less than 15 minutes. Users simply place a tiny amount of solution on the sensor, rinse the sensor, and then insert it into ASG\u2019s handheld testing system.<\/span><\/p>\n

\u201cWe\u2019re making it 15 times faster and 15 times lower cost to test for proteins,\u201d Black says. \u201cThat\u2019s on the drug development side. This could also make the manufacturing of drugs significantly faster and more cost-effective. It could revolutionize how we create drugs in this country and around the world.\u201d<\/span><\/p>\n

Since developing its sensor, ASG\u2019s team has received inquiries from a long list of people interested in using them to develop new therapeutics, help elite athletes train, and understand soil concentrations in agriculture, among other applications.<\/span><\/p>\n

For now, though, the small company is focusing on lowering barriers in health care by selling its low-cost sensors to companies developing and manufacturing drugs.<\/span><\/p>\n

\u201cRight now, money is a limiting factor in researching and creating new drugs,\u201d explains Marissa Gillis, a member of ASG\u2019s team.<\/span>\u00a0<\/b>\u201cMaking these processes faster and less costly could dramatically increase the amount of biologic testing and creation. It also makes it more viable for companies to develop drugs for rare conditions with smaller markets.\u201d<\/span><\/p>\n

A family away from home<\/b><\/h2>\n

Black grew up in a small town in Ohio before coming to MIT for three degrees in electrical engineering.<\/span><\/p>\n

\u201cGoing to MIT changed my life,\u201d Black says. \u201cIt opened my eyes to the possibilities of doing science and engineering to make the world a better place. Also, just being around so many amazing people taught me how to dream big.\u201d<\/span><\/p>\n

For her PhD, Black worked with the late Institute Professor Mildred Dresselhaus, a highly acclaimed physicist and nanotechnology pioneer who Black remembers for her mentorship and compassion as much as her contributions to our understanding of exotic materials. Black couldn\u2019t always afford to go home for holidays, so she\u2019d spend Thanksgivings with the Dresselhaus family.<\/span><\/p>\n

\u201cMillie was an amazing person, and her family was a family away from home for me,\u201d Black says. \u201cMillie continued to be my mentor \u2014 and I hear she did this with a lot of students \u2014 until the day she died.\u201d<\/span><\/p>\n

For her thesis, Black studied the optical properties of nanowires, which taught her about the nanostructures and optoelectronics she\u2019d eventually use as part of the Advanced Silicon Group.<\/span><\/p>\n

Following graduation, Black worked at the Los Alamos National Laboratory before founding the company Bandgap Engineering, which developed efficient, low-cost nanostructured solar cells. That technology was subsequently commercialized by other companies and became the subject of a patent dispute. In 2015, Black spun out the Advanced Silicon Group to apply a similar technology to protein sensing.<\/span><\/p>\n

ASG\u2019s sensors combine known approaches for sensitizing silicon to biological molecules, using the photoelectric properties of silicon nanowires to detect proteins electrically.<\/span><\/p>\n

\u201cIt\u2019s basically a solar cell that we functionalize with an antibody that\u2019s specific to a certain protein,\u201d Black says. \u201cWhen the protein gets close, it brings an electrical charge with it that will repel light carriers inside the silicon, and doing that changes how well the electron and the holes can recombine. By looking at the photocurrent when you\u2019re exposed to a solution, you can tell how much protein is bound to the surface and thus the concentration of that protein.\u201d<\/span><\/p>\n

ASG was accepted into MIT.nano\u2019s START.nano startup accelerator and MIT\u2019s Office of Corporate Relations Startup Exchange Program soon after its founding, which gave Black\u2019s team access to cutting-edge equipment at MIT and connected her with potential investors and partners.<\/span><\/p>\n

Black has also received broad support from MIT\u2019s Venture Mentoring Service and worked with researchers from MIT\u2019s Microsystems Technology Laboratories (MTL), where she conducted research as a student.<\/span><\/p>\n

\u201cEven though the company is in Lowell, [Massachusetts], I\u2019m constantly going to MIT and getting help from professors and researchers at MIT,\u201d Black says.<\/span><\/p>\n

Biosensing for impact<\/b><\/h2>\n

From extensive discussions with people in the pharmaceutical industry, Black learned about the need for a more affordable protein-measurement tool. During drug development and manufacturing, protein levels must be measured to detect problems such as contamination from host cell proteins, which can be fatal to patients even at very low quantities.<\/span><\/p>\n

\u201cIt can cost more than $1 billion to develop a drug,\u201d Black says. \u201cA big part of the process is bioprocessing, and 50 to 80 percent of bioprocessing is dedicated to purifying these unwanted proteins. That challenge leads to drugs being more expensive and taking longer to get to market.\u201d<\/span><\/p>\n

ASG has since worked with researchers to develop tests for biomarkers associated with lung cancer and dormant tuberculosis and has received multiple grants from the National Science Foundation, the National Institute of Standards and Technology, and the commonwealth of Massachusetts, including funding to develop tests for host cell proteins.<\/span><\/p>\n

This year, ASG announced a partnership with Axogen to help the regenerative nerve repair company grow nerve tissue.<\/span><\/p>\n

\u201cThere\u2019s a lot of interest in using our sensor for applications in regenerative medicine,\u201d Black says. \u201cAnother example we envision is if you\u2019re sick in rural India and there\u2019s no doctor nearby, you can show up at a clinic, nurses can give this to you and test for the flu, Covid-19, food poisoning, pregnancy, and 10 other things all at once. The results come in 15 minutes, then you could get what you need or teleconference a doctor.\u201d<\/span><\/p>\n

ASG is currently able to produce about 2,000 of its sensors on 8-inch chips per production line in its partner\u2019s semiconductor foundry. As the company continues scaling up production, Black is hopeful the sensors will lower costs at every step between drug developers and patients.<\/span><\/p>\n

\u201cWe really want to lower the barriers for testing so that everyone has access to good health care,\u201d Black says. \u201cBeyond that, there are so many applications for protein sensing. It\u2019s really where the rubber hits the road in biology, agriculture, diagnostics. We\u2019re excited to partner with leaders in every one of these industries.\u201d<\/span><\/p>\n

Source: <\/span><\/i>Zach Winn\u00a0<\/i><\/b>|<\/span><\/i>\u00a0MIT News<\/i><\/b><\/p>\n","protected":false},"excerpt":{"rendered":"

Protein sensor developed by alumna-founded Advanced Silicon Group can be used for research and quality control in biomanufacturing In the biotech and pharmaceutical industries, ELISA tests provide critical quality control during drug development and manufacturing. The tests can precisely quantify protein levels, but they also require hours of work by trained technicians and specialized equipment.\u2026<\/p>\n","protected":false},"author":2,"featured_media":19847,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_scj_primary_category_id":128,"_scj_featured":false,"_scj_featured_from":"","_scj_featured_until":"","_scj_featured_order":0,"_scj_visibility_class":"current","_scj_layout_family":"standard","_scj_article_style":"","_scj_display_overrides":[],"_scj_intro_image_id":19847,"_scj_intro_alt":"Startup\u2019s biosensor makes drug development and manufacturing cheaper","_scj_intro_caption":"","_scj_intro_class":"","_scj_intro_float":"","_scj_full_image_id":19847,"_scj_full_alt":"Startup\u2019s biosensor makes drug development and manufacturing cheaper","_scj_full_caption":"","_scj_full_class":"","_scj_full_float":"","_scj_media_type":"","_scj_media_provider":"","_scj_media_external_id":"","_scj_media_url":"","_scj_media_poster_id":0,"_scj_media_width":0,"_scj_media_height":0,"_scj_media_aspect_ratio":"","_scj_media_description":"","_scj_gallery_items":[],"_scj_related_post_ids":[],"_scj_additional_authors":[],"scj_layout_family":"standard","scj_media_provider":"","scj_media_url":"","scj_full_caption":"","footnotes":""},"categories":[128],"tags":[2669,241,247,4253],"class_list":["post-19848","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-business","tag-biomedical-devices","tag-digital-health","tag-medical-innovation","tag-nanotechnology"],"yoast_head":"\nStartup\u2019s biosensor makes drug development and manufacturing cheaper - thesmartcityjournal.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thesmartcityjournal.com\/en\/business\/startups-biosensor-makes-drug-development-and-manufacturing-cheaper\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Startup\u2019s biosensor makes drug development and manufacturing cheaper - thesmartcityjournal.com\" \/>\n<meta property=\"og:description\" content=\"Protein sensor developed by alumna-founded Advanced Silicon Group can be used for research and quality control in biomanufacturing In the biotech and pharmaceutical industries, ELISA tests provide critical quality control during drug development and manufacturing. 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