{"id":20114,"date":"2025-08-10T13:55:57","date_gmt":"2025-08-10T11:55:57","guid":{"rendered":"https:\/\/thesmartcityjournal.cibeles.net\/sin-categoria\/novel-cancer-killing-mechanism-opens-path-to-new-treatments\/"},"modified":"2025-08-10T14:03:12","modified_gmt":"2025-08-10T12:03:12","slug":"novel-cancer-killing-mechanism-opens-path-to-new-treatments","status":"publish","type":"post","link":"https:\/\/www.thesmartcityjournal.com\/en\/investigation\/novel-cancer-killing-mechanism-opens-path-to-new-treatments","title":{"rendered":"Novel cancer-killing mechanism opens path to new treatments"},"content":{"rendered":"

Researchers at Stanford have identified a new mechanism of cell death linked to the cancer drug candidate tegavivint, calling it a potential \u201cnew weapon in the battle against cancer\u201d<\/span><\/i><\/p>\n

A cancer drug currently undergoing clinical trials in human patients may work in a different way than previously understood.<\/span><\/p>\n

A Stanford-led research team has discovered a new type of cell death that is triggered by the cancer drug candidate tegavivint. The cell death process is distinct from the primary way the body kills off old or abnormal cells, known as apoptosis. Many current cancer treatments activate apoptosis \u2013 and, until now, tegavivint was believed to work this way as well.<\/span><\/p>\n

The discovery, detailed in the journal Nature Chemical Biology, has the potential to not only improve the future use of tegavivint but also help develop new treatments for killing cancer cells that are resistant to current therapies.<\/span><\/p>\n

\u201cThis could be a new weapon in the fight against cancer,\u201d said Scott Dixon, associate professor of biology and the study\u2019s senior author. \u201cWe\u2019ve shown a completely different way to attack the cancer by going after this new pathway. It remains to be established whether it ultimately is going to be useful, but certainly the door is open. We have a new opportunity here.\u201d<\/span><\/p>\n

A new kind of cell death<\/h2>\n

Cancer occurs when abnormal cells divide and grow, circumventing the body\u2019s normal cell death processes, so researchers are trying to find new and better ways to kill these resistant cells.<\/span><\/p>\n

Finding molecular cancer killers is the primary focus of Dixon\u2019s lab in Stanford\u2019s School of Humanities and Sciences. His team was working with a related chemical called CIL56 when colleague Mark Smith, director of medicinal chemistry at Stanford\u2019s Sarafan ChEM-H, mentioned the tegavivint trials. Dixon\u2019s team then started investigating how both compounds kill cancer cells.<\/span><\/p>\n

Through genetic investigations and comparisons to other cancer-killing compounds, they found evidence that both CIL56 and tegavivint caused cancer cells to die without triggering apoptosis. The two compounds also did not follow the pathways of any of the non-apoptotic types of cell death currently known.<\/span><\/p>\n

Instead, the researchers found that these compounds likely caused cancer cell death by creating a killer out of a usually innocuous type of fat, a lipid called palmitate, which is found in many dairy products and meat. More research is needed to understand the exact process of this type of cell death, but the researchers have preliminarily named it lipid-dependent necrosis or LiDN.<\/span><\/p>\n

A foundational find<\/h2>\n

None of the university researchers involved with this study has any connection to the company behind tegavivint, yet if the drug candidate ultimately is approved, their findings may benefit future patients.<\/span><\/p>\n

\u201cLooking ahead, we hope that this makes doctors\u2019 ability to use this drug even better,\u201d Dixon said. \u201cIf they have a better understanding of how it\u2019s really working, then maybe they\u2019ll be able to pick patients more effectively or better understand the effects that they might see.\u201d<\/span><\/p>\n

Dixon credits the discovery to foundational research as well as collaboration with other researchers at Stanford, including Everett Moding, a co-author on the study and assistant professor of radiation oncology in the School of Medicine.<\/span><\/p>\n

\u201cIt\u2019s really a combination of curiosity and serendipity that led us from CIL56 to this related molecule, tegavivint, which we realized had this unusual property,\u201d he said. \u201cOur main focus is understanding the details of how cells die, especially how cancer cells die. And just by spending a lot of time thinking about these problems, we could dissect something that might have been overlooked in earlier studies.\u201d<\/span><\/p>\n

Image: <\/span><\/i>Scott Dixon | Harrison Truong<\/span><\/i><\/p>\n

Dixon is also a fellow at Stanford\u2019s Sarafan ChEM-H and a member of Stanford Bio-X, the Stanford Cancer Institute, and the Wu Tsai Neurosciences Institute.<\/span><\/i><\/p>\n

Additional Stanford researchers on this study include Logan Leak, Ziwei Wang, Alby Joseph, Brianna Johnson, Alyssa Chang, Cassandra Decosto, Leslie Magtanong, Pin Joe Ko, Wavery Colleen Lee, Joan Ritho, and Sophia Manukian. Other collaborators include researchers affiliated with the University at Buffalo; The State University of New York; University of California, Los Angeles; the University of Massachusetts; the Broad Institute of MIT and Harvard; the University of Minnesota; and the University of Toronto. See the paper for full authorship details.<\/span><\/i><\/p>\n

This research received support from the National Institutes of Health, National Science Foundation, American Cancer Society, Lung Cancer Research Foundation, Manning Foundation\/IALS Innovation Award, Mass Ventures Funds, and Canadian Institutes of Health Research.<\/span><\/i><\/p>\n

This story was originally published by Stanford School of Humanities and Sciences.<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers at Stanford have identified a new mechanism of cell death linked to the cancer drug candidate tegavivint, calling it a potential \u201cnew weapon in the battle against cancer\u201d A cancer drug currently undergoing clinical trials in human patients may work in a different way than previously understood. A Stanford-led research team has discovered a\u2026<\/p>\n","protected":false},"author":2,"featured_media":20113,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_scj_primary_category_id":98,"_scj_featured":false,"_scj_featured_from":"","_scj_featured_until":"","_scj_featured_order":0,"_scj_visibility_class":"current","_scj_layout_family":"standard","_scj_article_style":"","_scj_display_overrides":[],"_scj_intro_image_id":20113,"_scj_intro_alt":"Novel cancer-killing mechanism opens path to new treatments","_scj_intro_caption":"","_scj_intro_class":"","_scj_intro_float":"","_scj_full_image_id":20113,"_scj_full_alt":"Novel cancer-killing mechanism opens path to new treatments","_scj_full_caption":"","_scj_full_class":"","_scj_full_float":"","_scj_media_type":"","_scj_media_provider":"","_scj_media_external_id":"","_scj_media_url":"","_scj_media_poster_id":0,"_scj_media_width":0,"_scj_media_height":0,"_scj_media_aspect_ratio":"","_scj_media_description":"","_scj_gallery_items":[],"_scj_related_post_ids":[],"_scj_additional_authors":[],"scj_layout_family":"standard","scj_media_provider":"","scj_media_url":"","scj_full_caption":"","footnotes":""},"categories":[98],"tags":[4367,297,2220],"class_list":["post-20114","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-cancer","tag-medical-research","tag-stanford-research"],"yoast_head":"\nNovel cancer-killing mechanism opens path to new treatments - thesmartcityjournal.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thesmartcityjournal.com\/en\/investigation\/novel-cancer-killing-mechanism-opens-path-to-new-treatments\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novel cancer-killing mechanism opens path to new treatments - thesmartcityjournal.com\" \/>\n<meta property=\"og:description\" content=\"Researchers at Stanford have identified a new mechanism of cell death linked to the cancer drug candidate tegavivint, calling it a potential \u201cnew weapon in the battle against cancer\u201d A cancer drug currently undergoing clinical trials in human patients may work in a different way than previously understood. 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