{"id":20431,"date":"2025-10-26T16:42:30","date_gmt":"2025-10-26T15:42:30","guid":{"rendered":"https:\/\/thesmartcityjournal.cibeles.net\/sin-categoria\/new-blood-test-for-early-detection-of-amyotrophic-lateral-sclerosis\/"},"modified":"2025-10-26T16:43:51","modified_gmt":"2025-10-26T15:43:51","slug":"new-blood-test-for-early-detection-of-amyotrophic-lateral-sclerosis","status":"publish","type":"post","link":"https:\/\/www.thesmartcityjournal.com\/en\/healthtech\/new-blood-test-for-early-detection-of-amyotrophic-lateral-sclerosis","title":{"rendered":"New blood test for early detection of amyotrophic lateral sclerosis"},"content":{"rendered":"<p><i><span style=\"font-weight: 400\">Researchers have identified proteins in the blood that can detect amyotrophic lateral sclerosis with great accuracy up to 10 years before symptoms appear.<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400\">Research supported in part by the EU-funded <\/span><a href=\"https:\/\/brainteaser.health\/\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400\">BRAINTEASER<\/span><\/a><span style=\"font-weight: 400\"> and <\/span><a href=\"https:\/\/hereditary-project.eu\/home\/\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400\">HEREDITARY<\/span><\/a><span style=\"font-weight: 400\"> projects has led to the identification of proteins in blood that can accurately detect amyotrophic lateral sclerosis (ALS) up to a decade before. These results, described in a <\/span><a href=\"https:\/\/www.nature.com\/articles\/s41591-025-03890-6\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400\">paper<\/span><\/a><span style=\"font-weight: 400\"> published in the journal \u2018Nature Medicine\u2019, pave the way for an urgently needed early diagnosis of this disease. ALS is a rare, fatal neurodegenerative disorder that affects motor neurons controlling voluntary muscle contraction, leading to progressive weakness and muscle degeneration.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">The disease is rapid and irreversible, increasing in incidence with age, and in most cases sufferers have a life expectancy of 2 to 5 years after the onset of symptoms. Approximately 32 000 people in Europe live with ALS, for which no definitive diagnostic test currently exists.<\/span><\/p>\n<h2>The light at the end of the tunnel<\/h2>\n<p><span style=\"font-weight: 400\">The research suggests that blood proteins could be a reliable biomarker for this degenerative condition. The team of scientists analysed close to 3 000 proteins from more than 600 individuals, examining not only patients with active ALS but also blood samples donated by people years before any symptoms of the disease emerged. Using machine learning, they identified a distinct protein signature that effectively differentiates ALS cases from healthy individuals and other neurological disorders.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">The model they created diagnosed the disease with more than 98 % accuracy, distinguishing patients with ALS from healthy people and those with other neurological diseases. \u201cWe see the light at the end of the tunnel here, and that target is an approved and available blood test for ALS,\u201d states study co-author Alexander Pantelyat of Johns Hopkins University School of Medicine in a <\/span><a href=\"https:\/\/hub.jhu.edu\/2025\/08\/29\/new-blood-test-for-als-detects-early-signs\/\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400\">news item<\/span><\/a><span style=\"font-weight: 400\"> posted on the university\u2019s website. \u201cWith a test that allows for earlier detection of ALS, we have opportunities to enroll people in observational studies, and by extension, offer promising disease-modifying\u2014and hopefully disease-stopping\u2014medications, before ALS becomes debilitating.\u201d By analysing blood samples from individuals before ALS symptoms emerged, the research team was able to estimate the age of clinical onset.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">They found that the disease process \u2013 which affects skeletal muscle, nerves and energy metabolism \u2013 occurs up to 10 years before any symptoms emerge. \u201cWe had always assumed that ALS was a rapid disease that starts 12 to 18 months before symptom onset,\u201d remarks Pantelyat. \u201cBut when we look at our findings, we see this has been a process that goes on for a decade or so before the patient ever steps into the doctor\u2019s office or clinic.\u201d The unique set of plasma proteins identified that distinguishes ALS from healthy individuals and other neurological diseases includes the NEFL protein, a proven ALS marker. What makes this study a real breakthrough is the discovery of 16 additional protein<\/span><\/p>\n<p><span style=\"font-weight: 400\">s that significantly increase ALS diagnosis accuracy. Identified using predictive modelling, these proteins show how proteomics and machine learning can offer new insights into complex diseases.\u00a0<\/span><\/p>\n<p><i><span style=\"font-weight: 400\">The BRAINTEASER (BRinging Artificial INTelligencE home for a better cAre of amyotrophic lateral sclerosis and multiple SclERosis) project ended in June 2025. HEREDITARY (HetERogeneous sEmantic Data integratIon for the guT-bRain interplaY) ends in December 2027.\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have identified proteins in the blood that can detect amyotrophic lateral sclerosis with great accuracy up to 10 years before symptoms appear. Research supported in part by the EU-funded BRAINTEASER and HEREDITARY projects has led to the identification of proteins in blood that can accurately detect amyotrophic lateral sclerosis (ALS) up to a decade\u2026<\/p>\n","protected":false},"author":2,"featured_media":20430,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_scj_primary_category_id":92,"_scj_featured":false,"_scj_featured_from":"","_scj_featured_until":"","_scj_featured_order":0,"_scj_visibility_class":"current","_scj_layout_family":"standard","_scj_article_style":"","_scj_display_overrides":[],"_scj_intro_image_id":20430,"_scj_intro_alt":"New blood test for early detection of amyotrophic lateral sclerosis","_scj_intro_caption":"","_scj_intro_class":"","_scj_intro_float":"","_scj_full_image_id":20430,"_scj_full_alt":"New blood test for early detection of amyotrophic lateral sclerosis","_scj_full_caption":"","_scj_full_class":"","_scj_full_float":"","_scj_media_type":"","_scj_media_provider":"","_scj_media_external_id":"","_scj_media_url":"","_scj_media_poster_id":0,"_scj_media_width":0,"_scj_media_height":0,"_scj_media_aspect_ratio":"","_scj_media_description":"","_scj_gallery_items":[],"_scj_related_post_ids":[],"_scj_additional_authors":[],"scj_layout_family":"standard","scj_media_provider":"","scj_media_url":"","scj_full_caption":"","footnotes":""},"categories":[92],"tags":[2235,2797,2852,2854,2853,183],"class_list":["post-20431","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-healthtech","tag-als-research","tag-biomarkers","tag-diagnostics","tag-healthtech","tag-neurology","tag-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New blood test for early detection of amyotrophic lateral sclerosis - thesmartcityjournal.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thesmartcityjournal.com\/en\/healthtech\/new-blood-test-for-early-detection-of-amyotrophic-lateral-sclerosis\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New blood test for early detection of amyotrophic lateral sclerosis - thesmartcityjournal.com\" \/>\n<meta property=\"og:description\" content=\"Researchers have identified proteins in the blood that can detect amyotrophic lateral sclerosis with great accuracy up to 10 years before symptoms appear. 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