{"id":20743,"date":"2026-01-18T19:36:37","date_gmt":"2026-01-18T18:36:37","guid":{"rendered":"https:\/\/thesmartcityjournal.cibeles.net\/sin-categoria\/study-reveals-promising-diet-for-managing-crohns-disease\/"},"modified":"2026-01-18T19:37:56","modified_gmt":"2026-01-18T18:37:56","slug":"study-reveals-promising-diet-for-managing-crohns-disease","status":"publish","type":"post","link":"https:\/\/www.thesmartcityjournal.com\/en\/investigation\/study-reveals-promising-diet-for-managing-crohns-disease","title":{"rendered":"Study reveals promising diet for managing Crohn\u2019s disease"},"content":{"rendered":"

Stanford Medicine researchers found a calorie-restrictive diet significantly alleviates symptoms of mild-to-moderate Crohn\u2019s disease, offering new guidance for patients<\/span><\/i><\/p>\n

\u201cWhat should I eat?\u201d is perhaps the most common question patients with inflammatory bowel disease ask their doctors.<\/span><\/p>\n

It\u2019s notoriously difficult to answer. There have been few large studies of dietary interventions for IBD, a group of disorders that includes ulcerative colitis and\u00a0<\/span>Crohn\u2019s disease<\/b><\/a>.<\/span><\/p>\n

Now, new research by Stanford Medicine investigators and their colleagues provides one potential answer. Their national, randomized controlled clinical trial found that a short-term, calorie-restrictive diet significantly improved both physical symptoms and biological indicators of mild-to-moderate Crohn\u2019s disease. The\u00a0<\/span>findings<\/b><\/a>\u00a0were published Jan. 13 in\u00a0<\/span>Nature Medicine<\/span><\/i>.<\/span><\/p>\n

While dietary interventions are difficult to study\u00a0\u2013 participants\u2019 reports of what they\u2019re eating aren\u2019t always accurate, and the placebo effect can\u2019t be avoided because participants know which diet they\u2019re on\u00a0\u2013 the findings were notable, demonstrating significant declines in objective markers of inflammation in biologic samples alongside improvements in clinical symptoms. The study may help physicians guide patients in finding a diet that alleviates symptoms.<\/span><\/p>\n

\u201cWe have been very limited in what kind of dietary information we can provide patients,\u201d said\u00a0<\/span>Sidhartha R. Sinha<\/b><\/a>, MD, an assistant professor of gastroenterology and hepatology, MD, an assistant professor of gastroenterology and hepatology and the senior author on the paper. \u201cThis study will give physicians evidence to support recommendations in an area that patients are very curious about.\u201d<\/span><\/p>\n

A common condition, few treatments<\/h2>\n

A chronic condition affecting about a million Americans, Crohn\u2019s disease causes inflammation in the digestive tract, leading to symptoms of diarrhea, cramping, abdominal pain and weight loss. Steroids are the only approved therapeutic for mild Crohn\u2019s, but their use is limited due to significant side effects, particularly with long-term use.<\/span><\/p>\n

The study compared the symptoms and biological indicators of patients with mild-to-moderate Crohn\u2019s disease as they either followed a fasting mimicking diet or ate their normal diet for three consecutive months. The study enrolled 97 patients across the country, with 65 in the fasting mimicking group and 32 in the control group.<\/span><\/p>\n

Participants in the fasting mimicking group severely limited their calories for five consecutive days per month, eating between about 700 and 1,100 calories a day, Sinha said. Plant-based meals were provided during the fasting period. For the remainder of the month, the fasting mimicking group ate their normal diet.<\/span><\/p>\n

At the end of the study, about two-thirds of the fasting mimicking group experienced improvement in their symptoms. \u201cWe were very pleasantly surprised that the majority of patients seemed to benefit from this diet,\u201d Sinha said. \u201cWe noticed that even after just one FMD cycle, there were clinical benefits.\u201d<\/span><\/p>\n

In the control group, less than half experienced improvements in their symptoms. The improvement was likely a result of natural symptom fluctuations in Crohn\u2019s disease and because patients continued to follow their standard care regimens, such as taking medications.<\/span><\/p>\n

Some participants in the fasting mimicking group experienced fatigue and headache, Sinha said, but no serious side effects were reported.<\/span><\/p>\n

Biological indicators get a boost<\/h2>\n

Sinha was inspired to study the fasting mimicking diet in patients with Crohn\u2019s disease after earlier research indicated the diet could reduce levels of C-reactive protein, a common marker of systemic inflammation in patients who had high baseline C-reactive protein levels. \u201cThe effects seen on inflammatory markers made this an appealing diet to study in Crohn\u2019s disease since many patients with this disease also have elevated inflammatory markers,\u201d he said.<\/span><\/p>\n

Along with tracking participants\u2019 clinical response and remission, the researchers also explored changes in biological specimens, such as shifts in common markers of inflammation in both stool and blood. \u201cOur goal in collecting these and other biospecimens was to dig deeper into why there\u2019s this differential response,\u201d Sinha said. \u201cCan we find mechanisms to explain the findings and signatures that might help predict patients who will respond to the diet?\u201d<\/span><\/p>\n

The researchers found a significant decline in fecal calprotectin, a protein in the stool that indicates gut inflammation, in the fasting mimicking group compared with the control group. Some inflammation-promoting lipid mediators derived from fatty acids also declined in fasting mimicking group participants. Similarly, the immune cells of fasting mimicking group participants produced fewer of several types of inflammatory molecules. The researchers are now exploring whether changes in the gut microbiome may also help explain some of the benefits of the fasting mimicking diet.<\/span><\/p>\n

\u201cThere\u2019s still a lot more to be done to understand the biology behind how this and other diets work in patients with Crohn\u2019s disease,\u201d Sinha said.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Stanford Medicine researchers found a calorie-restrictive diet significantly alleviates symptoms of mild-to-moderate Crohn\u2019s disease, offering new guidance for patients \u201cWhat should I eat?\u201d is perhaps the most common question patients with inflammatory bowel disease ask their doctors. It\u2019s notoriously difficult to answer. There have been few large studies of dietary interventions for IBD, a group\u2026<\/p>\n","protected":false},"author":2,"featured_media":20742,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_scj_primary_category_id":98,"_scj_featured":false,"_scj_featured_from":"","_scj_featured_until":"","_scj_featured_order":0,"_scj_visibility_class":"current","_scj_layout_family":"standard","_scj_article_style":"","_scj_display_overrides":[],"_scj_intro_image_id":20742,"_scj_intro_alt":"Study reveals promising diet for managing Crohn\u2019s disease","_scj_intro_caption":"","_scj_intro_class":"","_scj_intro_float":"","_scj_full_image_id":20742,"_scj_full_alt":"Study reveals promising diet for managing Crohn\u2019s disease","_scj_full_caption":"","_scj_full_class":"","_scj_full_float":"","_scj_media_type":"","_scj_media_provider":"","_scj_media_external_id":"","_scj_media_url":"","_scj_media_poster_id":0,"_scj_media_width":0,"_scj_media_height":0,"_scj_media_aspect_ratio":"","_scj_media_description":"","_scj_gallery_items":[],"_scj_related_post_ids":[],"_scj_additional_authors":[],"scj_layout_family":"standard","scj_media_provider":"","scj_media_url":"","scj_full_caption":"","footnotes":""},"categories":[98],"tags":[3229,3224,3225,3226,3228,3227],"class_list":["post-20743","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-clinical-research","tag-crohns-disease","tag-diet-therapy","tag-fasting-mimicking","tag-gut-health","tag-inflammation"],"yoast_head":"\nStudy reveals promising diet for managing Crohn\u2019s disease - thesmartcityjournal.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thesmartcityjournal.com\/en\/investigation\/study-reveals-promising-diet-for-managing-crohns-disease\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study reveals promising diet for managing Crohn\u2019s disease - thesmartcityjournal.com\" \/>\n<meta property=\"og:description\" content=\"Stanford Medicine researchers found a calorie-restrictive diet significantly alleviates symptoms of mild-to-moderate Crohn\u2019s disease, offering new guidance for patients \u201cWhat should I eat?\u201d is perhaps the most common question patients with inflammatory bowel disease ask their doctors. 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